Advanced glycation end products (AGEs)-receptor of advanced glycation end products (RAGE) signaling pathway is an important link in the occurrence and development of diabetic nephropathy, whose mechanism of action is mainly to activate the transcription of nuclear factor-κB (NF-κB) and stimulate the production of vascular endothelial growth factor (VEGF) [69], proving that VEGFA is a key target protein for the interaction between AD and tea polyphenols. This evidence concerns the gene VEGFA and Alzheimer disease.