The enrichment pathways identified following KEGG analysis that contained the most core targets (p < 0.05) included cocaine addiction, calcium signaling pathway, arginine biosynthesis, HIF-1 signaling pathway, pathways of neurodegeneration-multiple diseases, estrogen signaling pathway, chemical carcinogenesis-receptor activation, AD, complement and coagulation cascade, Gap junction and others (Figure 5). This evidence concerns the gene HIF1A and Alzheimer disease.