The production and accumulation of biological clock proteins were regulated by biological clock genes, and the proteasome-mediated degradation of core biological clock proteins and synaptic proteins contributed to the regulation of sleep quality [37], while an abnormal expression of biological clock genes caused by insomnia could lead to an excessive production and accumulation of biological clock proteins, the process that required a degradation of the proteasome. This evidence concerns the gene CLOCK and insomnia measurement.