The results obtained with these cells, which were transfected with clinically relevant SLX4 variants (SLX4 mutations identified in hereditary breast cancers), showed that certain missense mutations did not notably affect the sensitivity to olaparib (IC50: >1000 nM), whereas cells expressing a truncated SLX4 (after W823, missing TBM, SIM, SAP and CCD) were as sensitive to olaparib as SLX4-deficient cells (IC50: 50 nM) [13]. The gene discussed is SLX4; the disease is breast carcinoma.