ERCC1 and lung carcinoma: In lung cancer cells (NCI-H1299 and SK-MES-1) with increased or decreased ERCC1 expression, the sensitivity to a combination of cisplatin and olaparib was decreased when ERCC1 was overexpressed (50 vs. 68% survival in NCI-H1299, 11 vs. 17% survival in SK-MES-1 cells) and increased when ERCC1 was downregulated (12 vs. 6% survival in NCI-H1299, 28 vs. 9% survival in SK-MES-1 cells) [27].