When BRCA2-expressing and olaparib-resistant pancreatic cancer cells (CAPAN1-derived) were transfected to express Aurora-A (kinase involved in mitosis), cells were equally sensitive as untransfected BRCA2-deficient CAPAN1 cells to PARPi KU58948 in both in vitro (IC50: approximately 10 nM vs. 50 μM for untransfected cells) and in xenograft models [33]. This evidence concerns the gene BRCA2 and familial pancreatic carcinoma.