The inhibition of MUS81 expression by shRNA in human ovarian cancer cells (A2870 and SKOV3) induced a mild sensitization to olaparib (IC50: 4 vs. 7 μM for A2870, 6 vs. 9 μM for SKOV3) that was associated with an increase in the expression of MCM2 [43]. The gene discussed is MUS81; the disease is ovarian cancer.