In this context, analyzing the degranulation potential, lytic mediator content, IFγ secretion, expression of activating/inhibiting receptors, including checkpoint receptors, and killing activity (e.g., via performing killing assays using PMBC-derived NK cells and targeting colon cancer cell lines) of NK cells with regards to SARIFA in further studies would be extremely beneficial. Here, IFNG is linked to malignant colon neoplasm.