PKM and neoplasm: For instance, Zhou et al. [115] demonstrated a preponderant role of PKM2 in UBC initiation based on preclinical results, while Xia et al. [116] suggested that PKM2 is essential for UBC growth, by intersecting angiogenic and metabolic pathways, but not for tumour initiation; in this last study, the overexpression of PKM2 was found in both NMI low-grade and MI high-grade UBC tissue sections.