Wang et al. [74] recently demonstrated the use of HK2 as a single-cell sequencing-validated cellular marker for the high-throughput screening of highly glycolytic exfoliated UBC cells in urine, a method that showed sensitivity, specificity, positive predictive value, and negative predictive value superior to that of urinary cytology, accurately detecting BC before this standard method. The gene discussed is HK2; the disease is breast cancer.