HK2 has been described as a crucial mediator of glycolytic activity in BC promoted by the long non-coding RNA UCA-1 [77,78]; additionally, the microRNA-21 inhibition in UBC cell lines resulted in decreased glycolytic activity, as seen by the reduced HK2 activity [72], which highlights the importance of epigenetic modifications in the UBC cells’ metabolism. Here, HK2 is linked to breast cancer.