In these systems, a metabolic reprogramming toward a Warburg phenotype occurred as a result of the intercellular contact of fibroblasts and cancer cells, which triggered GLUT1 upregulation and lactate production and increased the expression of lactate transporters in both CAF and cancer cells; the CAF-produced lactate was uploaded by cancer cells via a reprogrammed aerobic metabolism. Here, SLC2A1 is linked to cancer.