In agreement with our animal studies, we found a significant association between CFTR mRNA expression in primary CRC tumors and 3-year disease-free survival of 90 persons diagnosed with stage II CRC [hazard ratio (HR) (95% confidence interval (CI)): 3.6 (1.20–10.77)], after adjusting for tumor location, differentiation, stage and microsatellite instability (MSI) status [10]. The gene discussed is CFTR; the disease is colorectal carcinoma.