To better understand the contribution of reduced CFTR expression to the outcomes in individuals with CRC in the population without CF, we expanded on our earlier study and investigated the association between CFTR expression and survival of individuals with CRC in three independent cohorts: the COADREAD [COAD(COlon ADenocarcinoma) and READ (REctum ADenocarcinoma)] study from The Cancer Genome Atlas Program (TCGA) [15], and two studies with data deposited in the NCBI Gene Expression Omnibus (GEO) database, GSE39582 [16] and GSE17538 [17,18,19,20]. This evidence concerns the gene CFTR and cystic fibrosis.