Integrative analysis revealed that the combined type cHCC-CCs show strong CC-like features, such as higher expression of EPCAM, KRT19, and PRDM5, as well as enrichment of KRAS mutations and higher expression of KRAS, whereas the mixed type cHCC-CCs show HCC-like features, such as higher expression levels of AFP, GPC3, APOE, and SALL4, as well as a higher level of serum AFP. Here, KRAS is linked to hepatocellular carcinoma.