Regulation of DNA replication and repair could also be modulated at the transcriptional level by E2F1, a client protein of HSP90 and HSP70 that assures the transcription of CDC6, CDC45, MCM4, MCM7, RIM1, and RIM2 in CLL [112,113]. The gene discussed is HSPA4; the disease is B-cell chronic lymphocytic leukemia.