Chronic inflammation of the intestinal epithelium, observed in patients with inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD), damages cell integrity, mainly through the accumulation of reactive oxygen species (ROS) and nitric oxygen species (NOS), which are produced by infiltrating leukocytes, activated macrophages, and neutrophils [1]. Here, NOS2 is linked to inflammatory bowel disease.