Indirect evidence comes from studies by Shi and colleagues, who treated mice bearing the CT26 and MC38 colon tumors with a combination of PLX3397 (an oral inhibitor of MCSF1R), anti-PD-1 antibody, and oncolytic viruses (OVs), which promote tumor T-cell infiltration due to their ability to selectively infect and kill tumor cells [85]. This evidence concerns the gene PDCD1 and neoplasm.