We found that BET inhibitors JQ1 and I-BET151 reduced TRAIL expression at the transcript (Figure 2C) and protein levels (Figure S2A) in MCF7 and A549 cells, in which the TRAIL coding region is associated with enhancer clusters, but not in the breast cancer cell line BT549, which lacks an enhancer cluster association with TRAIL. The gene discussed is TNFSF10; the disease is breast carcinoma.