Since we observed that (1) TRAIL protein can accumulate intracellularly, and in the nucleus, upon IFNα stimulation of the epithelial cancer cells we studied and (2) TRAIL can be upregulated in cancer due to epigenetic mechanisms usually found to be associated with oncogenes, a provocative possibility is that IFNα-upregulated TRAIL works as a pro-tumoral molecule in a group of epithelial cancer cells. The gene discussed is TNFSF10; the disease is cancer.