Importantly, ATAC-seq chromatin accessibility for regulatory elements 2, 4 and 7 strongly and positively correlated with TRAIL RNA levels from pan-cancer tumors (Pearson coefficients = 0.4438, 0.5131 and 0.5068, respectively; p < 0.0001), while regulatory element 8 showed a smaller but significant positive correlation (Pearson coefficient = 0.2380; p < 0.0001) (Figure 2B). The gene discussed is TNFSF10; the disease is cancer.