Our previous study reported that Beclin 1-targeting stapled peptides, including Tat-SP4 and another similar peptide with (i, i + 4) linkage for the hydrocarbon staple induced non-apoptotic cell death in NSCLC, breast cancer cells and hepatocellular carcinoma (HCC) cells [27,28,37]. This evidence concerns the gene BECN1 and hepatocellular carcinoma.