The detection of cancer cells in the lymph nodes can be restored to control levels upon re-expression of MMP13 in these RKIP expressing cells (Figure 1B); however, the effects of RKIP on extravasation and lung metastasis are MMP13 independent, as re-expression of MMP13 failed to reverse the effect due to the expression of RKIP. The gene discussed is PEBP1; the disease is cancer.