Moreover, FBXO43 knockdown also significantly suppressed cell growth and invasion of Huh7 cells (Supplementary Figure S5A–C), which expressed Y220C-mutated p53 without transcription activity [24], suggesting the FBXO43 exerted consistently oncogenic roles in both p53-wild and -mutant HCC cells. The gene discussed is TP53; the disease is hepatocellular carcinoma.