Particularly, several ubiquitin-conjugating enzymes, including UBE2C, UBE2T, and UBE2S that targeted p53 for degradation in cancers [20,21,22], were significantly upregulated in HCC tissues with high FBXO43 and positively correlated with FBXO43 expression in HCC tissues (Figure 5C,D and Supplementary Figure S3B,C). Here, UBE2C is linked to hepatocellular carcinoma.