The TCGA data demonstrated that, among four common m6A writers (METTL3, METTL14, METTL16, and WTAP), METTL3 was upregulated, highly associated with FBXO43, and predicted poor prognosis in HCC (Supplementary Figure S2C–E). The gene discussed is FBXO43; the disease is hepatocellular carcinoma.