TP53 and cancer: Particularly, several ubiquitin-conjugating enzymes, including UBE2C, UBE2T, and UBE2S that targeted p53 for degradation in cancers [20,21,22], were significantly upregulated in HCC tissues with high FBXO43 and positively correlated with FBXO43 expression in HCC tissues (Figure 5C,D and Supplementary Figure S3B,C).