We demonstrated that ATP-lyase high-IRS was associated with high-IRS of AR (OR: 1.71; p < 0.01) and FAS (OR: 4.82; p < 0.01), CPT-1a high-IRS was associated with AR (OR: 2.27; p < 0.05); IR-alpha (OR: 2.55; p < 0.01), IR-beta (2.45; p < 0.01), SCD (OR: 2.15; p < 0.01); SREBP (OR: 2.95; p < 0.01) and FAS (OR: 2.16; p < 0.01). The gene discussed is AR; the disease is Schnyder corneal dystrophy.