Furthermore, ACC-1 high IRS was an independent predictor of high IRS of AR (OR: 3.65; p < 0.01), PSMA (OR: 1.80; p < 0.01); IR-alpha (OR: 9.99; p < 0.01), SCD (OR: 2.63; p < 0.01); SREBP (OR: 2.53; p < 0.01) and with FAS (OR: 11.29; p < 0.01). This evidence concerns the gene AR and Schnyder corneal dystrophy.