PGE2 increases the expression of many factors relevant to tumorigenesis in GBM tumors—in particular, S100 calcium-binding protein A9 (S100A9) [151], interleukin 6 (IL-6) [152], and CXC motif chemokine ligand 8 (CXCL8)/interleukin 8 (IL-8) [153]. Here, IL6 is linked to glioblastoma.