In addition, two other mechanisms have been reported for ILC2s to directly restrain melanoma by inducing apoptosis thorough the secretion of the chemokines CXCL1 and CXCL2 in primary tumors and TNFα in lung metastases [52,53], suggesting that different anti-tumoral mechanisms may be specifically induced base on the TME. The gene discussed is TNF; the disease is melanoma.