Moreover, IL-10 in itself, which is produced by melanoma cells as an autocrine factor [87], appeared to be a more potent inhibitor of ILC2 secretory activity than TGF-β [88,89] and is known for its capability to further stimulate the suppressive activity of both Treg and MDSCs [23] (Figure 3C). The gene discussed is TGFB1; the disease is melanoma.