MYC stimulates cancer development through activating critical positive cell-cycle regulators, such as cyclins (cyclins D, E, A and B1), CDKs (CDK1, 2, 4 and 6) and E2F transcription factors (E2F1, 2 and 3), or by antagonizing cell-cycle repressors, such as p15, p21 and p27 [19]. The gene discussed is MYC; the disease is cancer.