Based on sparse published data, it has been suggested that RIPK4 can function as a tumor suppressor as well as an oncogene [21] since in some cancers, a high expression of RIPK4 is related to the development of tumors and correlates with a worse prognosis [21,22,23,24], while in others, RIPK4 levels decrease with tumor progression [25,26]. The gene discussed is RIPK4; the disease is cancer.