The lack of expression of the RIPK3 kinase in A375 cells, as well as in other melanoma cell lines, was demonstrated in a study by Geserick et al. The authors of this study indicate that the RIPK3 expression is lost with melanoma progression, protecting tumor cells from necroptosis despite the preserved expression of the RIPK1 kinase [52]. The gene discussed is RIPK3; the disease is neoplasm.