Although we showed that the expression of PEBP1 and RIPK4 is inversely correlated in melanocytes and melanoma, suggesting that RIPK4 blocks the degradation of the PEBP1 protein in metastatic melanoma, the downregulation of RIPK4 in melanoma cells had no effect on phosphorylation or upregulation of the PEBP1 protein. The gene discussed is RIPK4; the disease is metastatic melanoma.