BRAF and melanoma: Approximately half of advanced melanomas harbor mutations in codon 600 of BRAF (class I), with V600E (a switch from valine to glutamic acid resulting from substitution at the second position of codon 600 of nucleotide 1799 T > A; codon GTG>GAG) being the most common mutation substitution and the most common change (up to 90%) [3].