In a similar comparison with the TCGA COAD dataset, the KRAS, RYR1, LRP2, DYNC2H1, UNC80, PKHD1L1, FLG, KIAA2022, LAMA3, DPP10, NRXN1, TENM2, TNXB, YLPM1, ANKRD26, and LTBP2 genes showed a higher, while the APC, TTN, SYNE1, MUC16, FAT4, and ZFHX4 genes showed lower mutation frequencies in our CRC cohort (Figure 3b). The gene discussed is SYNE1; the disease is colorectal carcinoma.