CSMD3 and adenocarcinoma: CSMD3 was found to be mutated in 30/148 CRC patients documented by Wolff et al. [51], while it was altered with slightly lower frequency, in 8/51 CRCs in our cohort, and it was included in a 20-gene panel that can distinguish colorectal adenoma from adenocarcinoma, established by Lin et al. [55].