The top 20 genes mutated in the adenoma patients, but not identified in the CRC most frequently mutated genes, were the following: ELAC2 and MARCH6 in 3/27 of AD patients, and PCDHGB4, ACSM2B, AHRR, ANKRD30A, DEF8, DIS3L, HR, IGKV1D-17, ITIH1, KCNA5, KCNF1, KIAA0556, KIF4A, LPAR6, MUCL1, MYT1, NBPF1, and NCEH1 in 2/27 of AD patients (Figure 4b). The gene discussed is DEF8; the disease is Alzheimer disease.