Comparing our CRC data with the Chinese reference (COCA), a relatively higher mutation rate was detected (with a minimum of 5% difference), e.g., in the case of APC, KRAS, RYR1, LRP2, DYNC2H1, UNC80, PKHD1L1, DNAH5, DMD, CSMD3, SPTA1, BRAF, KIAA2022, LAMA3, DPP10, NRXN1, TENM2, TNXB, YLPM1, ANKRD26, and LTBP2, while in the case of MUC16, a lower percentage of cases was found among our CRC samples. The gene discussed is CSMD3; the disease is colorectal carcinoma.