Furthermore, HCC nodules resected from Socs1fl/flAlb-Cre mice showed increased expression of Cdkn1a, Nfe2l2, and the NRF2 target genes Gstm4, Gclc, and Nqo1, all of which showed lower expression in HCC nodules from Socs1fl/flSocs3fl/flAlb-Cre mice (Figure 3d). This evidence concerns the gene CDKN1A and hepatocellular carcinoma.