SOCS1 and neoplasm: Similar to Socs1fl/flAlb-Cre mice, Socs3fl/flAlb-Cre mice developed HCC with 100% penetrance and showed more tumor nodules than Socs3fl/fl controls (Figure 2d–h, Supplementary Figure S1), confirming the non-overlapping tumor suppressor functions of SOCS1 and SOCS3 [4,6].