Importantly, the benchmark NRF2 signature curated by Polonen and colleagues [42] revealed a highly significant enrichment in the SOCS1-low/SOCS3-high HCC group (NES = 1.4661141; p = 1 × 10−4; p. adjusted = 5 × 10−4) (Figure 4e). This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.