In a prospective randomized trial conducted by the Children’s Oncology Group (COG) in patients with relapsed or refractory neuroblastoma, pts treated with dinutuximab (ch14.18/SP2/0) combined with irinotecan, temozolomide, and granulocyte-macrophage stimulating factor (GM-CSF) showed an objective response rate of 41.5% [4]. Here, CSF2 is linked to neuroblastoma.