As mentioned earlier, several models have been proposed that can accurately predict ODX low- and high-risk categories [49,51,52,61,62,63,64,89,90], and some of these models also used routinely-reported pathological variables such as tumor morphology, tumor architecture, nuclear grade, mitotic count, ER, PR, HER2, and Ki-67 [49,51,52,61,62,63,64,89,90]. This evidence concerns the gene ESR1 and neoplasm.