Adaptive mechanisms coexist and include: enrichment of slow cycling JARID1B+ or drug efflux-prone ABCB5+ melanoma stem cells [4,5]; acquisition of a stress signature [6]; dedifferentiation toward a neural crest-like phenotype [6,7,8,9]; acquisition of an invasive MITF-low signature [6]; and acquisition of a MITF-high signature [10,11], resulting in increased pigmentation [6,12,13] and enhanced oxidative phosphorylation [14,15]. Here, MITF is linked to melanoma.