CD40LG and B-cell chronic lymphocytic leukemia: Another relevant observation was that the average levels of IgM ([IgM] = 102.3 μg/mL), IgG1 ([IgG1] = 102.9 μg/mL), and IgG2 ([IgG2] = 102.7 μg/mL) were increased in CLL-TFT with respect to the average levels in MBL ([IgM] = 102.2 μg/mL, [IgG1] = 102.8 μg/mL, and [IgG2] = 102.6 μg/mL), although the levels before the disease development could not be restored (IgM and IgA: 102.5–104 μg/mL) [20,42].