CD40LG and B-cell chronic lymphocytic leukemia: On the other hand, the fact that IgM average levels were increased in the samples of CLL-TFT ([IgM] > 102 μg/mL) with respect to CLL-PFT ([IgM] < 102 μg/mL) and MBL ([IgM] > 102 μg/mL) was due to the type of therapy received (treatment with ibrutinib).