In a further analysis according the clinical/diagnosis groups, several patterns were observed: (i) IgG3 and IgA decreased according to disease evolution (c-CLL to p-CLL) (Supplementary Figure S2B); (ii) the Ig serum levels were constant in the MBL and c-CLL subsets, but a reduction in the Ig concentration was observed in the CLL-PFT subset, and slight increase in the Ig serum levels was observed in the CLL-TFT subset (Supplementary Figure S2C); and (iii) the mutational status was also reflected in reduced IgG1 serum levels when U-IGHV and M-IGHV were compared (Supplementary Figure S2D). Here, IGHG3 is linked to B-cell chronic lymphocytic leukemia.