In addition, these B-CLLs commonly present IgM in their membranes (Ig reactive to a wide variety of antigen epitopes); however, the autoimmunity developed by these CLL patients seems to be restricted to aAgs mostly expressed by blood cells (erythrocytes, platelets, and granulocytes) and mediated by IgG autoantibodies (aAbs) [5,19]. The gene discussed is CD40LG; the disease is B-cell chronic lymphocytic leukemia.