Epithelial-to-mesenchymal transition is associated with loss of E-cadherin expression resulting in loss of cellular adhesion and polarity that leads to an invasive cell phenotype with increased metastatic potential [42,46,47].Previous studies have described EMT in the setting of PTC characterized by over-expression of vimentin in addition to increased tumor invasion and lymph node metastases [48]. The gene discussed is VIM; the disease is neoplasm.