While there is a consensus between the type of irAE and ICI class, as colitis and hypophysitis are more common with anti-CTLA4 and pneumonitis and thyroiditis with anti-PD-(L)1 therapy, this analysis was not performed in our study due to the low percentage of patients treated with anti-CTLA4 [25]. The gene discussed is CTLA4; the disease is thyroid gland disorder.