UM is molecularly distinct from cutaneous melanoma (CM), and the two diseases are characterized by entirely different driver mutations; B-Raf Proto-Oncogene (BRAF), NRAS Proto-Oncogene (NRAS), and Neurofibromin 1 (NF1) [5] in CM; and G Protein Subunit Alpha Q (GNAQ) and 11 (GNA11), and BRCA1- associated Protein 1 (BAP1) [6,7,8] in UM. This evidence concerns the gene BAP1 and cutaneous mastocytosis.