Micro-dissected FFPE (formalin-fixed paraffin embedded) tumor tissues from Tg(mitfa:p38α);Tg(mitfa:NRASQ61K);mitfaw2;tp53zdf1 (p38–NRASQ61K, in short) versus Tg(mitfa:NRASQ61K);mitfaw2;tp53zdf1 (NRASQ61K, in short) were clustered based on RNA sequencing and observed 517 DEGs (two-fold change, p-value < 0.01) (Figure 8A). The gene discussed is MITF; the disease is neoplasm.