We investigated the long-term effects of p38 overexpression by treating NRAS-mutant melanoma cells for 24 h with anisomycin, by stable transfection of p38 in cell lines, and by transgenic modification in Tg(mitfa;NRASQ61K)mitfaw2;tp53zdf1 zebrafish. The gene discussed is NRAS; the disease is melanoma.