FOXO1 and metastatic neoplasm: The authors identified the overexpression and underexpression of 180 and 68 miRNAs in cancer samples, respectively, including the overexpression of miR-222 (target genes KIT and AXIN2), miR-15a (target genes AXIN2 and FOXO1), and miR-221 (target gene KIT) and the underexpression of miR-206 (target gene MET), miR-299-3p (target gene ITGAV), miR-103 (target gene ITGA2), and miR-101 (target gene ITGA3), which was also downregulated in the group of patients with indolent metastatic disease in our study.