A meta-analysis of 2019 publications on DNA methylation markers in HCC identified six aberrantly methylated genes (RASSF1A, PCDKN2A, CDH1, RUNX3, GSTP1, and WIF1) in the serum of HCC patients compared to the serum of healthy individuals [45]. Here, RASSF1 is linked to hepatocellular carcinoma.