Exosomes containing EBV dUTPase protein have been reported to induce NF-κB activation and cytokine secretion (IL-1β, IL-6, IL-8, IL-10, IL-12p70, TNF-α and IFN-γ) in primary human DCs and PBMCs through a Toll-like receptor 2 (TLR2) mechanism [39,40,41,42] and to convert phagocytes into tumor-associated macrophages (TAMs) via induction of the inflammatory response [119]. This evidence concerns the gene TLR2 and neoplasm.