Simultaneous pharmacological blocks of aquaporin and AMPA/kainate receptors could present a powerful approach for slowing invasive cell spread, based on recent findings in GBM cell lines (Varricchio et al., 2022, in review) showing the augmented effects of AMPA/kainate channel inhibitors when combined with AqB013, a bumetanide derivative which blocks water passage through AQP1 and AQP4 [229]. Here, AQP1 is linked to glioblastoma.