Blockers of AQP1 that slow colon cancer migration and invasion include bumetanide derivatives AqB007 and AqB011, which inhibit the AQP1 cation channel; 5-hydroxylmethyl furfural, which also blocks the AQP1 ion channel; and Bacopasides I and II from the medicinal plant Bacopa monnieri, which preferentially block the AQP1 ion channel and water pores, respectively [151]. This evidence concerns the gene AQP1 and colonic neoplasm.