FISH analysis for MYC was detected in 87 (72%) cases of blastoid HGBL (Table 2), including 22 cases of blastoid HGBL-NOS with MYC-R alone and 65 cases of blastoid D/THL carrying concurrent BCL2 and/or BCL6 rearrangements. The gene discussed is BCL6; the disease is high grade B-cell lymphoma.