There were 55 (45%) cases of HGBL not otherwise specified (NOS); 22 (40%) had isolated MYC-rearrangement (MYC-R), 9 of 38 (24%) had BCL2-rearrangement (BCL2-R), and 2 of 37 (5%) harbored BCL6-rearrangement (BCL6-R). The gene discussed is BCL2; the disease is high grade B-cell lymphoma.