EGFR and non-small cell lung carcinoma: Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is currently indicated as first-line therapy in patients with non-small-cell lung cancer (NSCLC) and sensitizing EGFR mutations; as second-line therapy in patients who present the resistance-associated mutation T790M after treatment with previous EGFR-TKIs; and as adjuvant therapy for patients with early stage, resected NSCLC, harboring EGFR mutations.