Given the clinical, histological and biological similarities with LRCHL, nodular lymphocyte pre-dominant and T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL), it is plausible that immunosuppressive effect of TGF-β plays an important role in a certain population of DLBCL [112,113,114]. This evidence concerns the gene TGFB1 and diffuse large B-cell lymphoma.