Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 C>G (p.I148M) [2,3,4,5,6] and transmembrane 6, superfamily member 2 (TM6SF2) rs58542926 C>T [7,8,9] have been associated with non-alcoholic steatohepatitis (NASH) and alcohol-related HCC and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 C>T has been associated with NAFLD-related HCC [10]. Here, TM6SF2 is linked to metabolic dysfunction-associated steatohepatitis.