In addition, the “proliferative” class included HCC of the G3 transcriptomic class that are associated with a poor prognosis, enriched in TSC1 and TSC2 mutations and FGF19/CCND1 amplification and characterized by a peculiar histological phenotype known as “macrotrabecular massive”, easily identified by the pathologist at liver biopsy or on surgical sample [24,57,60]. The gene discussed is FGF19; the disease is hepatocellular carcinoma.