Inactivating mutations of AT-rich interaction domain containing protein 1A (ARID1A) and 2 (ARID2), which encode key components of SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes, have been described in up to 10–15% and 5–8% of HCC cases, respectively, and lead to the repression of genes regulated by the transcription factor E2F [26,35]. This evidence concerns the gene ARID2 and hepatocellular carcinoma.