In agreement, regarding data of the GENIE project (2281 melanoma samples in total), among the 224 BRAF V600K mutated samples, 14 also carried the PPP6C R264C mutation (6.3%), while only 13/1269 (1%) samples carried concomitant BRAF V600E and PPP6C R264C mutations (Fisher’s Exact Test—p-value = 0.000006506) (Supplementary Figure S1). Here, BRAF is linked to melanoma.