The top positively enriched gene sets in MES-like samples concern KRAS signalling, extracellular matrix organisation and the invasiveness of tumours coupled with an increased inflammatory response, while the top negatively enriched pathways include mechanisms such as DNA repair and protein folding, metabolic processes such as glycolysis and oxidative phosphorylation, and cell-cycle mitotic events that promote cell proliferation (Figure 8A,C). This evidence concerns the gene KRAS and neoplasm.