BRAF and melanoma: In the case of the TCGA Pan-Cancer Atlas (448 melanoma samples in total), among the 35 BRAF V600K mutated samples, 5 also had the R264C mutation in PPP6C (14.3%), while only 2/158 (1.3%) samples carried concomitant BRAF V600E and PPP6C R264C mutations (Fisher’s Exact Test—p-value = 0.00242).