Indeed, HPV infection is only the first step in the HPV-driven carcinogenesis, and many additional genetic and signaling alterations involving p53 and Rb degradation by E6 and E7, respectively, as well as PI3K/AKT/mTOR signaling, are required for HPV infection to ultimately lead to HPV-associated cancer [17,31,32,33]. This evidence concerns the gene AKT1 and cancer.