For example, HAS2-AS1 plays an important role in glioblastoma, oral squamous cell carcinomas, and non-small cell lung cancer, and is tightly regulated by several transcription factors including HIF-1α, NF-kB, Sp1, Sp3, high-mobility group AT-hook 2 (Hmga2), signal transducer and activator of transcription 1 (STAT1), and CAMP responsive element binding protein 1 (CREB1). Here, HMGA2 is linked to non-small cell lung carcinoma.