18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (DCFPyL) or Fluorine-18 Piflufolastat (Pylarify) is the newest PET imaging agent, and it combines the accuracy of PET with the precision of PSMA targeting to identify PSMA-avid loco-regional disease and metastatic disease. This evidence concerns the gene FOLH1 and metastatic neoplasm.