For example, OR51E2 is ~10-fold more highly expressed in EVs than the Cell fraction (Figure S1) but was only useful as a PCa-biomarker in the Cell fraction, therefore if the two fractions were combined it is likely that the high EV expression would obscure the difference in expression between the NC and PCa groups seen in the cell-sediments. The gene discussed is OR51E2; the disease is posterior cortical atrophy.