Thirteen probes/fraction combinations were significantly differentially expressed between NC and PCa in the Cell and EV expression data (FDR p < 0.05; edgeR; Table 3; data presented as a Volcano plot in Figure 2A)—7 in EVs and 6 in Cell; all were overexpressed in cancer apart from CDKN3, SPINK1 and UPK2. This evidence concerns the gene UPK2 and cancer.