MKI67 and neoplasm: The prognosis for patients with a NET depends partly on histologic grading; grade 1 NET (G1, mitotic count less than 2/2 mm2 and Ki-67 less than 3%) has a better prognosis compared to grade 2 (G2, mitotic rate 2–20/2 mm2 and Ki-67:3–20%) or grade 3 (G3, mitotic rate greater than 20/2 mm2 and Ki-67 index greater than 20%) tumours [2].