There are also several other oncogenes in which somatic changes lead to the development of pancreatic tumours, including genes BRCA1, BRCA2, PALB2, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1 [18,19,20]. This evidence concerns the gene SMAD4 and pancreatic neoplasm.