SMAD4 and pancreatic ductal adenocarcinoma: In addition, Zhang et al. detected recurrent somatic mutations in multiple genes, including KRAS, TP53, CDKN2A, SMAD4, ARID1A and CDKN2B, in 1080 Chinese patients with pancreatic ductal adenocarcinoma, demonstrating the genomic characteristics on a large scale [28].