For example, calcium signaling has been reported to be involved in the proliferation of Ras-driven cancers through the interaction between calmodulin and PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) [103,104] and the promotion of invasion and metastasis via ERK activation in both BRAF- and non-BRAF-driven CM cells [104,105]. The gene discussed is BRAF; the disease is cancer.