FTH1P3 (ferritin heavy chain 1 pseudogene 3) showed increased expression in a cohort of twenty-five tumor samples compared to non-tumor matched tissues; this upregulation sustained increased cell proliferation and migration in vitro, promoted RAC1 (Rac family small GTPase 1) and Frizzle 5 (FDZ5, frizzled class receptor 5) expression, and induced downregulation of miR-224-5p, which in turn reduced the expression of the lncRNA in a loop regulative mechanism. This evidence concerns the gene FZD5 and neoplasm.