Similarly, both in the phase 1b KEYNOTE-173 and the phase 2 randomized I-SPY2 clinical trials, which respectively evaluated the combination of pembrolizumab plus neoadjuvant chemotherapy in early TNBC and HER2-negative BC, a correlation between baseline sTILs or T cell density and pCR emerged [26,27]. The gene discussed is ERBB2; the disease is breast cancer.