Notably, a recent retrospective analysis including 563 patients with early HR+/HER2- BC showed that CD8+ sTILs were higher in patients with PIK3CA-mutated tumors (OR: 1.65; 95% CI: 1.03–2.68) and that, in this PIK3CA-mutated subpopulation, they are associated with a higher risk of recurrence (HR: 1.98; 95% CI: 1.14–3.41) on multivariate analysis, while CD4+ and FOXP3+ sTILs failed to demonstrate a prognostic value [52]. Here, PIK3CA is linked to breast cancer.