The signals of an inverse prognostic role of TILs emerging in this subset of BC may be further investigated considering the high heterogeneity of HR+/HER2+ BCs, which includes two different intrinsic subtypes, namely luminal A and luminal B tumors, respectively characterized by a higher and lower dependence on endocrine signaling and by different prognoses [53,54]. This evidence concerns the gene ERBB2 and breast cancer.