As far as the prognostic role of TILs in early HR+/HER2- BC is concerned, evidence from large retrospective studies is discordant: while some studies did not show a prognostic role of TILs in this subtype [49,50], others displayed an association between high TILs and a worse prognosis in terms of risk of recurrence and OS [51,52]. Here, ERBB2 is linked to breast cancer.