Our findings highlighted the specific IEI genes underlying non-hematologic malignancies including ATM deficiency (n = 7), AIRE deficiency (n = 2), IKZF1 deficiency (n = 1), PI3KR1 deficiency (n = 2), IL12RB1 deficiency (n = 2), and STAT1 gain-of-function (n = 2). Here, IL12RB1 is linked to hyperinsulinemic hypoglycemia, familial, 4.