EGFR and astrocytoma (excluding glioblastoma): Now, IDHwt astrocytoma with a Telomerase Reverse Transcriptase Promoter (pTERT) mutation, EGFR alteration or chromosome 7 gain/chromosome 10 loss are automatically classified as grade IV IDHwt glioblastoma, despite the absence of histological necrosis and angiogenesis.