As shown in Figure 4, compounds 12a and 13d work in the same way and most pronouncedly affect the STAT5, STAT3, Akt and p38 kinases in the tumor cell at a concentration of 0.006 and 0.004 μM, which affects the number of phosphorylated forms of various kinases compared to the control. This evidence concerns the gene STAT3 and neoplasm.