Patients with ascites were associated with lower serum albumin levels, higher bilirubin levels, higher creatinine levels, lower sodium levels, prolonged prothrombin time, higher platelet count, higher serum α-fetoprotein (AFP) levels, large and multiple tumors, higher rate of vascular invasion, higher CTP, ALBI and EZ-ALBI score, poor performance status, advanced Barcelona Clinic Liver Cancer (BCLC) stage, and a higher rate of receiving non-curative treatments or best supportive care as compared with those without ascites (all p < 0.001). Here, AFP is linked to Ascites.