In univariate analysis of the entire cohort (n = 4431), gender, older age, HBV infection, low platelet count, lower serum albumin level, higher serum bilirubin, creatinine, ALT, and α-fetoprotein (AFP) level, coagulopathy, presence of vascular invasion, distant metastasis, presence of diabetes mellitus, ALBI grade 2 and grade 3, poor performance status, non-curative treatment, tumor size, tumor nodule and total tumor volume, and presence of ascites were associated with decreased survival in the Cox multivariate model 1 (Table 2). The gene discussed is AFP; the disease is diabetes mellitus.